When a radioactive mutant tentacle gains superhuman intelligence and decides to conquer the world, a trio of nerdy friends must intervene. Bernard Bernoulli and his companions Laverne and Hoagie travel to a remote motel to answer an urgent distress call, only to find themselves entangled in a mad scientist's plan to prevent catastrophe. Desperate to stop the creature's scheme at its root, Dr. Fred sends the group backward through time—but a malfunctioning device scatters them across different historical periods, each racing against the clock to reverse the mutation before it's too late.