In 2173, human colonies spread across Mars and the moons of Jupiter mine a resource called Metatron, but Earth's grip on the colonists—derisively called Enders—is absolute. Discrimination is open and ordinary. Cage Midwell, a seventeen-year-old worker on the interplanetary ship Bonaparte III, discovers a woman hiding in the cargo hold and follows her—only for the ship to be attacked by a powerful black Orbital Frame. Cage and the woman, who calls herself Myona Alderan and has no memory of who she is, escape in a mysterious LEV and crash-land on Mars. Accused of causing the disaster, they are imprisoned until a rebel faction called BIS (Born in Space), led by Deckson Geyse, breaks them free. Cage finds himself at the center of the escalating war between Earth and its colonies.