Jack Carver accepts a charter job taking journalist Valerie Cortez to a remote Pacific archipelago, only to have his boat destroyed by hostile mercenaries upon arrival. Stranded and hunted, Jack learns that Valerie is actually a CIA operative and that the island is home to Dr. Krieger, a rogue scientist developing a serum that unlocks primal abilities in human subjects. After being captured and injected with the serum himself, Jack gains superhuman speed, strength, and heightened senses, but must fight his way through Krieger's forces and the mutant creatures they have created in order to escape the island alive.