In the year 2099, Miguel O'Hara, the Spider-Man of his era, investigates Alchemax scientist Walker Sloan and uncovers a dangerous plot: Sloan intends to travel back in time to found the powerful corporation decades before its true origin, rebuilding history in his own image. O'Hara fails to stop Sloan from stepping through his time gateway and is briefly trapped between dimensions, where he witnesses a chilling vision of his predecessor, Peter Parker, being killed by an unknown assailant. Returning to a drastically altered version of 2099, O'Hara uses archived DNA to forge a mental link across time with Parker, working in the past, to warn him of his impending death. As the two Spider-Men are drawn together, they discover that every action in one era now ripples directly into the other.