A year after the death of his Uncle Ben, Peter Parker continues to fight crime in New York City as Spider-Man, still searching for the criminal who got away. When that trail is cut short by a serial killer who targets other criminals, Spider-Man sets out to bring the so-called Carnage Killer to justice. His pursuit draws him into a citywide turf war among rival gangs and the rise of a privatized enforcement group backed by powerful business interests. Along the way Spider-Man crosses paths with figures such as an idolizing engineer, a seasoned hunter who offers to mentor him, and his ailing friend Harry Osborn, each of whom complicates his fight to protect the city.