Months after the events of the 2012 film, Manhattan enjoys an uneasy peace that shatters when Oscorp's illegal cross-species experiments escape their containment, unleashing creatures carrying a devastating virus through the city's population. Spider-Man must race to contain the biological catastrophe while partnering with Gwen Stacy and a conflicted Dr. Curt Connors to develop a cure before the outbreak spirals beyond control. Adding pressure to the crisis, Oscorp's ruthless new leader Alistair Smythe pursues his own cure—not to save the city, but to seize credit and eliminate both Spider-Man and Connors as obstacles to his ambitions. Torn between fighting the infection and outmaneuvering corporate corruption, Spider-Man must prevent Manhattan from descending into chaos.