A seasoned hunter named Fabius encounters a mysterious boy called Nata emerging from the Forbidden Lands, a desolate and previously unexplored territory believed to be empty of human life. The child belongs to the Keepers, a displaced people driven from their homeland by the White Wraith, a legendary monster presumed long extinct. To help Nata return home and solve the enigma surrounding this creature's reappearance, Fabius recruits a newly promoted hunter and their palico companion, assembling an expedition team alongside the guild handler Alma and blacksmith Gemma to form the Avis Unit. As they push into the dangerous wilderness, the group must contend with relentless monsters and hostile environmental forces while pursuing the White Wraith through an unforgiving landscape where they also aid the Forbidden Lands' indigenous inhabitants in their struggle for survival.