Humanity faces extinction in 2199 as relentless alien invaders from Gamila bombard Earth with radioactive meteorites, forcing the last survivors underground as their world becomes a poisoned wasteland. A desperate message reaches them from the distant planet Iscandar, offering a glimmer of salvation: a technology capable of restoring the planet's contaminated surface. To retrieve this salvation, humanity's finest engineers transform the wreckage of a legendary World War II battleship, the Yamato, into a formidable military spacecraft equipped to pierce through the enemy's iron blockade. With dwindling time before radiation poisoning claims the last human lives on Earth, the crew embarks on a perilous interstellar journey across hostile space, knowing that failure means the complete annihilation of their species.