Construction workers on the remote colony world of Vega 4 inadvertently breach an underground Alien hive during excavation, releasing the creatures onto the surface and overwhelming the city of New Shanghai. The distress call that follows reaches not only Earth but also a passing Predator vessel, whose crew recognizes the infestation as an irresistible hunting opportunity. Players take on the role of a Predator warrior, pursuing the extraterrestrial swarm through six progressively dangerous stages across varied environments, each presenting encounters with specialized Aliens that bear the anatomical traits of their host species—aquatic variants, simian hybrids, winged creatures, and serpentine abominations among them. The hunt culminates in a distant confrontation within the Orion Nebula, where the player must face the ultimate threat: the Alien queen itself.