Five years after the original supernatural crisis, the Ghostbusters find themselves drawn back into paranormal investigation when malevolent forces resurface in New York City. The team must track down spectral entities while gathering ectoplasmic residue and experimenting with different combinations to strengthen their arsenal against increasingly dangerous threats. As circumstances spiral beyond their control, they discover an ancient evil—Vigo, a powerful entity with a sinister history—orchestrating events from the shadows. The Ghostbusters race to understand and confront this formidable enemy before his plans come to fruition, facing both supernatural obstacles and unexpected legal troubles along the way.