Two freedom fighters embark on a frantic mission to penetrate the stronghold of the sinister Dr. K before time runs out. Armed with explosives and a arsenal ranging from conventional firearms to experimental weaponry, the pair must navigate treacherous terrain including crumbling rooftops, industrial wastelands, and hazardous natural obstacles like lava flows and toxic sludge. Across sixteen increasingly demanding stages, they face off against genetically engineered adversaries in fast-paced cooperative combat where quick reflexes and improvisation—including hand-to-hand combat when necessary—become crucial to survival. The anarchic nature of the conflict means conventional tactics take a backseat to pure instinct and cunning.