Set in Yokohama in the year 2197, a sprawling international megalopolis where organized crime has flourished and lone vigilante fighters chase the justice that official channels cannot provide. Private detective Brian takes on a case that begins simply: an assault on a woman in the brothel known as "John Wayne." Digging deeper, Brian finds the attack connected to a web of crimes that leads into dangerous biological experimentation. With policewoman Akane, bounty hunter Ridley, and a circle of unlikely allies at his side, Brian pieces together a picture far larger and more sinister than any single crime.