In the distant past of imperial Japan, breakthroughs in a mysterious discipline known as "meta-topology" fueled the unexpected prosperity of the Heian era. The scientists behind these discoveries founded a specialized university devoted to bio- and nano-technology research. Because women held the dominant position in that society, it was they who became imbued with meta-topological powers — calling themselves "meta-women." A cycle of conflict between reactionary governments and the meta-women persisted across thousands of years, carrying into the future. Now Mayumi Tanaka — president of the university's astronomy department — leads a group of young women fighting to preserve their existence and the powers they were born to carry.