In the 22nd century, scientists learned to merge human and animal DNA to create powerful creatures called Gears. A tournament is held; whoever wins must then face a Gear that has gone rogue and is threatening to lead the Gears in open rebellion against humanity. The game features familiar Guilty Gear characters including Sol Badguy — a man with a deep personal connection to the Gear phenomenon — and Ky Kiske, commander of the Holy Knights. A new character named Fanny, a nurse who fights with a syringe, makes her debut here with an unexplained connection to the infamous surgeon Dr. Baldhead. The presentation uses a super-deformed art style, but the combat retains the core mechanics of the main series: tension meter, combo routing, and powerful special attacks.