Fear Effect 2: Retro Helix opens in Hong Kong in 2048, delving into the backstories of the original trio of mercenaries and newcomer Rain Qin, and the unlikely circumstances that bring them together. The world is reeling from a degenerative global pandemic called EINDS (Environmentally Induced Nucleotides Degeneration Syndrome, pronounced "ends"), and theft, murder, and terrorism have become thriving industries.
Hana Tsu-Vachel and Rain Qin work as freelance operatives, Royce Glas is a washed-up ex-soldier, and Jacob "Deke" Decourt is a ruthless assassin. Much of the intrigue lies in how these mismatched allies ever come together for a single cause; each begins with private motives but is gradually drawn into a sinister conspiracy that reaches far beyond politics, espionage, or survival. The adventure carries players through a futuristic Hong Kong, the imposing walled city of Xi'an, the lost tomb of China's first emperor, and finally the mountain island of the immortals, Penglai Shan.