Alex Murphy died in the line of duty in Detroit and was resurrected by OCP as RoboCop—a cyborg officer built to enforce the law in a city the corporation sees primarily as a real estate opportunity. The 2003 game sets Murphy against a new crisis: the designer drug "Brain Drain" is flooding Neo-Detroit's streets, and crime lord William Nexx controls its distribution. A heated mayoral race is running in parallel, and OCP's involvement in all of it is almost certainly significant, though the specifics remain carefully obscured.