Tokyo, 2049. Three beings who appear human live together—but the front cover of Crimson Tears tells the truth the game eventually confirms: they are mutanoids, bio-engineered weapons manufactured by a corporation called A.R.M.A. Their home has been destroyed, and the three are now operating in an unfamiliar world that doesn't know what they are. Crimson Tears is a hack-and-slash action RPG with a dungeon-crawl structure, in which the mutanoids' engineered combat capabilities are their primary resource in a city that has no place for them.