Set three years after the events of Crash Bandicoot: The Wrath of Cortex — which left the villainous Doctor Neo Cortex and the mighty Uka Uka stranded in the Antarctic sea — this adventure finds N. Sanity Island menaced by a sinister pair known as the Evil Twins. The threat forces Crash Bandicoot into a reluctant alliance with his arch-nemesis and creator, Doctor Neo Cortex, the very target the Twins have come seeking revenge against.