Cartman is not dead. He is planning revenge on a cosmic scale — transforming the entire universe into copies of himself. Stan, Kenny, and Wendy must fight through thirty levels to stop him, facing the original Cartman variants alongside new ones: Cartmans with jetpacks, Snakoid Cartmans, heavily armed Cartmans built to absorb punishment, and more. The adventure adds underwater sections, moving platforms, and puzzle sequences to the mayhem.