The story opens in 2005, as the counter-terrorist operative Bishop leads fellow Rainbow agents Logan Keller and Gabriel Nowak through a tense hostage rescue in the Pyrénées, a mission complicated by Nowak's impulsiveness. Five years later, Bishop takes command of Bravo Team, made up of Mike Walter and Jung Park, and is sent to the Las Vegas area after the National Security Agency uncovers a dangerous plot. Two smugglers, the brothers Miguel and Alvarez Cabreros, are suspected of moving chemical weapons out of Mexico and into the city. As Bishop's team races to intercept the weapons, they are drawn into a spiraling crisis of hostage situations and hidden bombs, forcing them to hunt the terrorists across Las Vegas before catastrophe strikes.