Five years ago, Kakeru's older sister died. He has been trying to build a normal life since, and his childhood friend Yuka has been helping. One day the sky turns red and the moon turns black — everyone except Kakeru and Yuka disappears, replaced by monsters roaming the empty streets. Then everything returns to normal. When the Red Night happens a second time, they find four other humans caught in the same phenomenon. Six join together to survive. Then six shadows appear in front of them.