Atelier Annie: Alchemists of Sera Island introduces Annie, a self-described lazy girl who wants nothing more than to sleep the day away. Her grandfather finally loses patience and, while she dozes, arranges for her to be sent to Sera Island to take part in a large-scale resort development project — a rude awakening in more ways than one.
Annie wakes in an unfamiliar room staring at a small boy named Pepe, who wastes no time informing her that she will be learning alchemy whether she likes it or not. The resort project, it turns out, depends on it. What follows is not a complete disaster for Annie's ambitions, however: the contestant who contributes most to the project earns the title of Meister — and will be betrothed to the Prince of Orde. Marriage into royalty is more than enough motivation to make the laziest alchemist in history get to work.