The Crogenitors were a galaxy-spanning empire of scientists who created armies from genetically engineered heroes called Living Weapons. Everything changed with the discovery of E-DNA, an experimental amino acid capable of compressing millennia of evolution into hours—and proving devastatingly unstable. Every test subject it touched mutated into an uncontrollable creature. The scientist Xylan, exiled for negligence, faked his death, injected himself with E-DNA, and transformed into the Corruptor—a mentally unstable, omnipotent mutant who can command all Darkspore. Bent on revenge, the Corruptor began systematically conquering Crogenitor worlds using E-DNA bombs and mutant armies. Players take the role of one of the last remaining Crogenitors, working through a roster of genetic heroes to reclaim planet after planet and ultimately destroy the Corruptor.