In 1991, AMS rookie agent G teams with Detective Isaac Washington to investigate a series of disappearances and a mutant outbreak across Bayou City, Louisiana. Their initial target is Papa Caesar, a crime lord Isaac has personal reasons to pursue—Caesar ordered his father's death. Caesar eludes them, but his disabled associate Jasper Guns does not: injecting himself with an unknown substance to survive their confrontation, Jasper mutates into one of the game's early boss encounters. After defeating him, they encounter Jasper's sister Varla, a stripper with her own grievances against Caesar and reasons to help. The House of the Dead: Overkill - Extended Cut adds two new stages to the original Wii release.