Piro is a pagan farmer from Perugia, Italy, driven to violence by the rise of Christianity. His rampage begins at the church hosting his grandparents' silver wedding anniversary. Killed shortly afterward, Piro is judged in the afterlife by a foul-mouthed, short-tempered God — and depending on the player's choices, either fights and kills Him or finds a way to escape. Back on Earth, Piro devises a plan to prevent Christianity from ever existing by traveling back in time and killing Jesus before the religion can take root. Grezzo 2 is one of the most deliberately and aggressively blasphemous video games in Italian gaming history.