The head of the 3rd Street Saints ascends to the presidency after thwarting a major terrorist threat, only to face an even greater catastrophe when an intergalactic force known as the Zin launches a devastating invasion of Earth. The president and several gang members are imprisoned within a digital recreation of Steelport, a computer-generated world designed to contain them. With help from allies who have managed to escape the simulation and manipulate its code to unlock extraordinary powers, the player must liberate their imprisoned comrades, shatter the digital prison holding them hostage, and mount a resistance against the alien occupation.