An aging delivery driver named Conway embarks on what should be his final job: transporting an antique to a remote Kentucky address that refuses to materialize on any map. Accompanied only by his dog, he navigates the backroads near Interstate 65 until desperation leads him to a ramshackle gas station, where an enigmatic attendant reveals the unsettling truth—the destination lies accessible only through Route Zero, a legendary highway existing outside the ordinary world. What follows is a surreal descent into the forgotten margins of the American South, where the line between reality and dream grows increasingly blurred as Conway traces the mysterious road toward his unknown destiny.