Tales of the Black Death follows Baldasar across three installments. In Part 1, set in Italy, the death of his parents from an unexplained illness marks him as an outcast, and he finds the only companionship available in a traveling thief — together surviving disease, bandits, and death. In Part 2, fleeing to France as the Black Death spreads, Baldasar takes on the role of protector to a young girl searching for her missing mother across a landscape of desperate people and increasingly grim odds. In Part 3, befriending two army deserters and making his way to London at the height of the pandemic, Baldasar finds a city eaten alive by death and must choose: goodness or vengeance. Survival is tracked through injury, illness, and infection. Moral choices throughout the story affect the characters around the player and the shape of the ending that becomes available.