Ten years after the events of Doom II, Earth's governments are attempting to rebuild a civilization that was nearly ended by the war against Hell. Cabalco — latent until now — has chosen this moment to seize the old UAC facilities and build a portal generator capable of resurrecting Tchernobog and reconstituting the Cabal's fallen army. A miscalibrated collider during the portal construction creates a space-time disturbance: the universe of Blood and the universe of Doom II collapse into a fragmented shared space called the Void, pulling both their armies into contact. Cabalco engineers created Hybrids — creatures combining Hell demons with Cabal forces — to serve them. For once, Doomguy is not alone. The Void brought Caleb with him. Together, they fight.