Vampire Survivors is loosely set in rural Italy in 2021, where hordes of monsters conjured by the villainous Bisconte Draculó — an homage to Count Dracula — overrun the countryside. In answer, the Belpaese family and a band of other plucky survivors take it upon themselves to hunt the fiend down, fighting their way through monster-infested haunts like a cursed forest, a haunted library, an abandoned dairy plant, a sinister tower, and an otherworldly chapel, all building toward a showdown with an eldritch entity called "The Directer." Curiously, despite the game's title, the heroes never actually face any vampires.